Pain Mechanisms
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Pain is a sensation that warns of potential injury and alerts the person to avoid or treat it. For example, if you touch a hot object, you will feel pain and immediately remove your hand from that object, protecting your hand from further damage. As much as pain can burden and torment, ultimately it is…
Read MoreGastrointestinal Regulatory Substances
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As we eat, our gastrointestinal (GI) system releases a host of both local and distant regulators to control the process of digestion. We will begin with the primary hormones, then cover some of the secondary hormones, and lastly discuss how our body senses its intraluminal contents and then subsequently integrates all of the various stimuli…
Read MoreMigraine, Cluster, and Tension Headaches
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Headaches are an unavoidable fact of life and often are nothing more than the result of sitting through one too many lectures. However, they can become debilitating and get in the way of daily life, especially when they become recurrent. Although some headaches have symptoms other than head pain, we typically think of headache pain…
Read MorePatent Ductus Arteriosis
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he ductus arteriosus (DA) is a structure that allows blood pumped from the right side of the heart to bypass the lungs while the fetus is developing in utero. Normally, the DA closes shortly after birth and becomes the ligamentum arteriosum. When the DA fails to close (remains open, or patent) after birth, it is…
Read MoreCongenital Disorders of the Reproductive Systems
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In typical reproductive system development, recall that the intermediate mesoderm forms the mesonephric (Wolffian) and paramesonephric (Müllerian) ducts and the indifferent gonads; primitive germ cells migrate into the indifferent gonads. These are the structures that become the internal organs of the reproductive systems. After listening to this AudioBrick, you should be able to: Describe the…
Read MoreSubstance Use Disorders: Foundations and Frameworks
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Substance use disorder (SUD) refers to a pattern of substance use—be it nicotine, cannabis, cocaine, or something else—that causes significant impairment or distress to the user. SUD is prevalent and growing in the United States and around the world. People of any age may be at risk for developing a substance use disorder. But exposure…
Read MoreStimulants and Cognitive-Enhancing Drugs
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Stimulant medications are drugs that increase alertness and attention. They also elevate heart rate, blood pressure, and respiratory rate. Stimulants are used to treat many conditions, including attention-deficit/hyperactivity disorder (ADHD), chronic lethargy, narcolepsy, and obesity. Examples of stimulants include caffeine, amphetamines (such as dextroamphetamine), methylphenidate, and modafinil. Cognitive-enhancing drugs serve a similar purpose, increasing memory,…
Read MoreHematopoietic Malignancies: Putting It All Together
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If you’ve studied the hematopoietic system malignancies—all the leukemias, lymphomas, and plasma cell disorders—you probably feel like you’ve been hit with the good old medical school fire hose. Now’s a good time to take a step back from all the details, make sure that you remember the underlying framework, and pull together some information that…
Read MoreSubstance Use Disorders: Foundations and Frameworks
![The Rx Bricks Podcast The Rx Bricks Podcast](https://usmle-rx.com/wp-content/uploads/2020/09/AudioBricks_CoverArt-1-150x150.png)
Substance use disorder (SUD) refers to a pattern of substance use—be it nicotine, cannabis, cocaine, or something else—that causes significant impairment or distress to the user. SUD is prevalent and growing in the United States and around the world. People of any age may be at risk for developing a substance use disorder. But exposure…
Read MoreMegaloblastic Anemia
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Megaloblast. Now there’s a word you don’t hear every day. The root -blast (from the Greek blastos, meaning germ or bud) may be somewhat familiar since we talk about blast cells (very young hematopoietic precursor cells) in hematology. And megalo- (from the Greek megas, meaning large or great) is also used fairly frequently, as in splenomegaly (enlargement…
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