Hemophilia is a bleeding disorder resulting from defects in factors of the coagulation cascade. There are two primary types of hemophilia: A and B. Both types of hemophilia are rare, with only a combined frequency of about 1 in 5000 live births. Of the two types, hemophilia A is about four times more common. In the intrinsic arm of the coagulation cascade, factor VIII serves as a cofactor for factor IX. They cooperate to activate factor X, leading to the formation of fibrin.
After listening to this AudioBrick, you should be able to:
- Compare and contrast the underlying defect in hemophilia A and B.
- Describe the inheritance pattern and relative incidence of hemophilia A and B.
- Describe the clinical features of hemophilia A and B.
- Explain how hemophilia A and B are diagnosed.
- List and briefly describe other factor deficiencies.
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